to disagree with or object to something/somebody对…有异议；不同意；反对
I have no problem with you working at home tomorrow.你明天在家里工作，我没有意见。
(informal)We are going to do this my way. Do you have a problem with that?(= showing that you are impatient with the person that you are speaking to)这件事将按照我的方法来做，你有什么意见吗？